Physical fitness levels of wheelchair-bound children and adolescents with osteogenesis imperfecta: a feasibility and reliability study

Completed

Conditions: brittle bone disease
Osteogenesis imperfecta
10028396

Registration Number: NL-OMON39147

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

Wheelchair-bound patients with OI:
* Boys and girls aged 8 to 25 years,will be enrolled;
* Diagnosis of OI and using a wheelchair (for long distances);
* Modified Bleck score * Treated at the the ORSK consulting-hour, UMC Utrecht or Isala Klinieken;
* Sufficiently healthy to participate.;Healthy peers:
* Age- and gender-matched healthy peers will be enrolled;
* Prepubescent, pubescent, and postpubescent children.

Exclusion Criteria

Wheelchair-bound patients with OI:
* A medical status that contraindicates exercise (e.g. cardiomyopathy);
* The use of medication affecting exercise capacity;
* Unable to cooperate with the testing procedures (e.g. insufficient understanding of the Dutch language).;Healthy peers:
* A medical status that contraindicates exercise;
* The use of medication affecting exercise capacity;
* Cardiovascular or respiratory disease;
* Impaired motor development;
* Morbid obesity (body mass index (BMI) >35 kg/m2);
* Unable to cooperate with the testing procedures (e.g. insufficient understanding of the Dutch language).

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Reliability (test re-test reliability/reproducibility) of the shuttle ride test<br /><br>;<br /><br>Validity of the shuttle ride test (attained peak heart rate and peak<br /><br>respiratory exchange ratio);<br /><br>Maximal oxygen consumption (VO2peak) attained during the shuttle ride test<br /><br>(health-related fitness);<br /><br>Rating of perceived exertion directly after the shuttle ride test.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Muscle force (grip strength and one-stroke push test);<br /><br>Fatigue (18-item PedsQL multidimensional fatigue scale);<br /><br>Activities in daily life (wearing an accelerometer for one week).</p><br>