Rate of multidrug resistance to antimicrobial drugs in paediatric neurointensive care patients

Not yet recruiting

• Conditions: Resistance to other antimicrobialdrugs,

• Registration Number: CTRI/2019/10/021721
• Lead Sponsor: All India institute of medical sciences

Brief Summary

INTRODUCTION:The global rise in use of antibiotics has led to development of resistant bacteria and increasing costs in healthcare. 1Paediatric patients are a high risk population subgroup for acquiring Healthcare Associated infections.Our aim is To measure burden of antimicrobial resistance in paediatric neurointensive care patients.

MATERIALS &METHODS:This prospective observational cohort study will enroll all operative neurosurgical pediatric patients aged between 1-18 year admitted in neurointensive care unit during one year period after approval from institutional ethics committee. Daily monitoring of risk factors, including devices, mechanical ventilation, laboratory indices, cultures, sensitivities, length of NSICU stay, and their final outcome, either discharge or death, will be recorded.The data collection will be  done on a predesigned proforma. The specific HAI-type will be diagnosed according to clinical and laboratory criteria set by Centers for Disease Control and Prevention. Clinical samples for microbiological culture comprise of blood, urine, pus, CSF and endotracheal aspirates and will be sent once infection is suspected according to clinical criteria set by CDC.

REVIEW OF LITERATURE:In a prospective study conducted in 2016 by El-Nawawy et al the incidence of Paediatric Intensive care unit-acquired episodes in was found to be 13.63(n=36/264episodes),which was equivalent to15.6 cases/1,000 patient days.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2019-10-17
• Study Start: 2020-01-01

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Age:1-18 years 2.
• All elective and emergency intracranial and spine surgeries.

Exclusion Criteria

• Age: >18 yrs 2.
• Non consenting patients 3.
• Patients with high risk of MDRO colonisation: antibiotic exposure history (within last 3 months) presence of underlying diseases, previous surgery (within last 1 month) exposure to other MDRO colonized patients, patients transferred from other facilities known to have a high prevalence of MDRO carriage, history of recent hospital or nursing home stays.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine Rate of Multidrug resistance to antimicrobial drugs	One year

Secondary Outcome Measures

Name	Time	Method
To determine organisms and risk factors leading to Multidrug resistance	One year

Trial Locations

Locations (1)

AIIMS; 🇮🇳 Delhi, DELHI, India

AIIMS

🇮🇳Delhi, DELHI, India

Swapnil Patel

Principal investigator

9582086707

swapnil_doc@yahoo.com