Low Anterior Resection Syndrome (LARS) in Ovarian Cancer Patients - a Multi-centre Comparative Analysis.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 125
- 主要终点
- functional bowel outcome after low anterior resection
研究概览
简要总结
Background:
Low anterior resection syndrome (LARS) is a common functional disorder after low anterior resection impacting quality of life. Data on LARS derives nearly exclusively from rectal cancer studies. Therefore, the study was designed to assess LARS in advanced epithelial ovarian cancer (EOC) patients, who underwent rectal resection and to compare it with a female rectal cancer cohort.
Methods:
A cross-sectional multi-centre analysis was performed for female patients suffering from either rectal or EOC who received a low anterior resection as part of their therapy regimen. None of the patients received pre- or postoperative radiotherapy. LARS was defined by using the validated LARS score and its severity was divided into "no", "minor" and "major LARS".
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •low anterior resection because of ovarian or rectal cancer
排除标准
- •neoadjuvant or adjuvant radiotherapy
结局指标
主要结局
functional bowel outcome after low anterior resection
时间窗: 1 year
low anterior resection syndrome score, questionnaire via telephone call or personal contact
次要结局
未报告次要终点
研究者
Felix Harpain
Principle Investigator, M.D.
Medical University of Vienna