Study by Electroencephalography of the Link Between the Lack of Self-compassion and the Disorder of Empathy in Schizophrenia

Not Applicable

Completed

• Conditions: Schizophrenia; Schizoaffective Disorder

• Registration Number: NCT05464563
• Lead Sponsor: Centre Hospitalier Henri Laborit

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-4-21
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Inclusion Criteria for the patient group :<br><br> - patients with a schizophrenic or schizoaffective disorder according to the DSM-5<br> criteria (axis 1), with no other pathology of axis 1, except addiction to tobacco<br><br> - patients stabilized for at least 3 months for their psychotic disorders<br><br> - patients with disease duration > 2 years but < 20 years<br><br> - patients whose treatment has not been changed or modified in the previous month<br><br> - patients on stable treatments who should not change treatment during the study (good<br> compliance, good tolerance)<br><br> - patients who do not benefit from a neuromodulation protocol for their symptoms<br> (rTMS, TDCS)<br><br> - patients who do not benefit from a cognitive remediation program<br><br> - patients between the ages of 18 and 60<br><br> - men and women<br><br> - patients with normal or corrected vision<br><br> - patients without mental impairment<br><br> - patients without neurological impairment (epilepsy, encephalopathy, head trauma)<br><br> - patients with a sufficient command of French<br><br> - patients free or under protective measures<br><br> - patients benefiting from coverage by a social security scheme or benefiting from it<br> through a third party<br><br> - Having given their consent to participate in the study after having received<br> written, clear and fair information (and after obtaining the consent of the<br> tutor/curator if applicable)<br><br>Exclusion Criteria for the patient group :<br><br> - patients with an axis 1 pathology other than a schizophrenic or schizoaffective<br> disorder (in particular, psychic trauma revealed by MINI and symptoms of PTSD<br> (current as lifetime))<br><br> - patients with an addiction to alcohol or other toxic substances, except tobacco<br><br> - patients with suicidal intentionality<br><br> - patients not stabilized for their psychotic disorders and with regard to their<br> antipsychotic treatments<br><br> - patients receiving antiepileptic treatment with mood-regulating, antidepressant and<br> anxiolytic properties<br><br> - patients receiving benzodiazepine treatment that they could not stop 72 hours before<br> the EEG<br><br> - patients with disease duration < 2 years or > 20 years<br><br> - patients with an IQ < 70<br><br> - patients benefiting from a neuromodulation protocol (rTMS, TDCS)<br><br> - patients benefiting from a cognitive remediation program<br><br> - patients with a PANSS > or = 5 for items G8 (hostility) and P7 (non-cooperation)<br><br> - patients aged < 18 years or > 60 years<br><br> - patients with mental impairment<br><br> - patients with neurological impairment (epilepsy, encephalopathy, head trauma)<br><br> - patients with documented neurological pathology or medical condition that may<br> explain the psychotic manifestations<br><br> - patients who do not speak French well enough<br><br> - subjects residing within a radius greater than 50 km from the hospital<br><br> - patients hospitalized under duress<br><br> - patients without social security<br><br>Inclusion Criteria for the control group:<br><br> - healthy volunteers without schizophrenic or schizoaffective disorder and without<br> other psychiatric pathologies as defined by the DSM 5 (axis 1) (in particular,<br> absence of psychic trauma revealed by the MINI and of PTSD (current as whole life))<br><br> - subjects aged 18 to 60<br><br> - men and women<br><br> - subjects with normal or corrected vision<br><br> - subjects without mental impairment<br><br> - subjects without neurological impairment (epilepsy, encephalopathy, head trauma)<br><br> - free subjects, without guardianship or curatorship or subordination<br><br> - subjects benefiting from coverage by a social security scheme or benefiting from it<br> through a third party<br><br> - Having given their consent to participate in the study after having received<br> written, clear and honest information.<br><br>Exclusion Criteria for the control group:<br><br> - subjects with a psychiatric pathology as defined in the DSM-5 (axis 1) (in<br> particular, psychic trauma revealed by the MINI and symptoms of PTSD (current as<br> lifetime))<br><br> - subjects aged < 18 years or > 60 years<br><br> - subjects with a mental deficiency<br><br> - subjects with neurological pathology<br><br> - subjects with a medical condition preventing them from participating in the study<br><br> - subjects residing within a radius greater than 50 km from the hospital<br><br> - subjects under guardianship or curatorship<br><br> - subjects not benefiting from a Social Security scheme or not benefiting from it<br> through a third party

Exclusion Criteria

Not provided

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation between the temporal parameters of the EEG microstates C, D, E and F (duration, contribution, occurrence) and the inter-subject correlation index during the practice of self-compassion and the practice of empathy.