The Role of Inflammation in AMD and Related Disorders

• Conditions: Age-Related Macular Degeneration
• Interventions: Procedure: multi-modal cSLO imaging

• Registration Number: NCT02588378
• Lead Sponsor: Unity Health Toronto

Brief Summary

This prospective, non-therapeutic study will compare the relative utility of multiple ocular imaging modalities in the detection of the cellular immune response in patients with AMD and related disorders.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-04
• Study First Submitted: 2015-10-26
• Study First Submitted QC: 2015-10-26
• Study First Posted: 2015-10-27
• Status Verified: 2019-05
• Last Update Submitted: 2019-05-21
• Last Update Posted: 2019-05-23
• Primary Completion: 2020-05
• Study Completion: 2020-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Early dry AMD (no GA)	multi-modal cSLO imaging	multi-modal cSLO imaging
Late dry AMD (with GA)	multi-modal cSLO imaging	multi-modal cSLO imaging
Polypoidal Choroidal Vasculopathy (PCV)	multi-modal cSLO imaging	multi-modal cSLO imaging
Reticular Pseudodrusen (RPD)	multi-modal cSLO imaging	multi-modal cSLO imaging
Central Serous Retinopathy (CSR)	multi-modal cSLO imaging	multi-modal cSLO imaging
Healthy (non-AMD) controls	multi-modal cSLO imaging	multi-modal cSLO imaging
Retinal Angiomatous Proliferaion (RAP)	multi-modal cSLO imaging	multi-modal cSLO imaging
RPE Detachment (RPED)	multi-modal cSLO imaging	multi-modal cSLO imaging
New onset CNVM (wet AMD)	multi-modal cSLO imaging	multi-modal cSLO imaging

Primary Outcome Measures

Name	Time	Method
Visualization of RPE damage and presumptive immune cells	8 months	Qualitative

Trial Locations

Locations (1)

St Michael's Hospital; 🇨🇦 Toronto, Ontario, Canada