Biomarker research on the association between the effect and the HPV infection on the multimodal therapy for oropharyngeal squamous cell carcinoma
Not Applicable
- Conditions
- Oropharyngeal squamous cell carcinoma
- Registration Number
- JPRN-UMIN000021572
- Lead Sponsor
- The study group of basic research of the head and neck
- Brief Summary
Among 80 samples, HPV positive oropharyngeal squamous cell carcinoma was 56 cases and HPV negative was 24 cases. Among HPV positive cases HPV16 was 49 cases, HPV35 was 3 cases respectively. In HPV positive samples, PIK3CA was the most common genomic alteration, the second one was FGFR3 and the third one was PTEN. In HPV negative samples, TP53 was most frequently altered. HPV positive patients had significantly better overall survival and disease free survival than HPV negative.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
Not provided
Exclusion Criteria
Patient with surgical treatment Distant metastasis Double cancer
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The efficacy of multimodal therapy and HPV infection for oropharyngeal carcinoma
- Secondary Outcome Measures
Name Time Method