Comparative effect of resuscitation with hypertonic saline versus normal saline after extracorporeal circulation during cardiovascular surgery in the Intensive Care Unit (ICU)

Phase 3

Active, not recruiting

• Conditions: Crystalloid resuscitation after valve replacement surgery and coronary artery bypass surgery that underwent extracorporeal circulation; Anaesthesiology - Other anaesthesiology; Cardiovascular - Other cardiovascular diseases; Surgery - Other surgery

• Registration Number: ACTRN12615000466549
• Lead Sponsor: Ray Mendoza Franco

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-05-13
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: All
• Target Recruitment: 102

Inclusion Criteria

Patients with signed informed consent older than 18 years old
Patients admitted in the ICU after valve replacement surgery or coronary artery bypass surgery that underwent extracorporeal circulation

Exclusion Criteria

Patients that withdraw the informed consent by himself or by their family at any time during the intervention
Heart transplant surgery
Patients that do not fulfill the study protocol

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The blood lactate sample was obtained from central venous catheter immediately after the admission of the patient in the ICU and then again after 6 hours, 12 hours and 24 hours.<br><br>Lactate is measured in the laboratory by chemical oxidation method.<br>[Assessed on admission of the patient in the ICU and then again after 6 hours, 12 hours and 24 hours.]

Secondary Outcome Measures

Name	Time	Method
The cardiac index was measured by the thermodilution principle with a pulmonary artery catheter after the admission of the patient in the ICU and then again at 30 minutes, 4 hours, 6 hours, 12 hours and 24 hours.[Assessed on admission of the patient in the ICU and then again at 30 minutes, 4 hours, 6 hours, 12 hours and 24 hours.];The sample of mixed venous oxygen saturation was obtained with a pulmonary artery catheter after the admission of the patient in the ICU and then again at 30 minutes, 4 hours, 6 hours, 12 hours and 24 hours.<br><br>I - Stat system was used for measuring the mixed venous oxygen saturation.[Assessed on admission of the patient in the ICU and then again at 30 minutes, 4 hours, 6 hours, 12 hours and 24 hours.];ICU hospitalization length[time of ICU hospitalisation];mortality[28 days]