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临床试验/CTRI/2025/09/094299
CTRI/2025/09/094299尚未招募Phase 3 4

Role of plantago major mother tincture in aqueous solution on oral microbiome: a comparative study with conventional methods

Post Graduate Dissertation1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2025年9月22日最近更新:

试验速览

阶段
Phase 3 4
状态
尚未招募
发起方
入组人数
30
试验地点
1
主要终点
CHANGE IN THE MICROBIAL DIVERSITY AND LOAD

研究概览

简要总结

Maintaining oral health is essential for preserving the balance of the oral microbiome and preventing both dental and systemic diseases Conventional mouthwashes such as chlorhexidine are widely used but often associated with side effects like staining altered taste and microbial resistance Plantago major a medicinal plant with known antiinflammatory antimicrobial and woundhealing properties presents a promising alternative for natural oral care This experimental study investigates the clinical efficacy and patient acceptability of an aqueous solution of Plantago major mother tincture compared to conventional oral hygiene methods including toothpaste and oil pulling

The study was conducted at Sarada Krishna Homoeopathic Medical College Tamil Nadu involving 30 participants aged 10 to 70 years Participants were randomly divided into three groups Group 1 used an aqueous solution of Plantago major 1:9 dilution as a primary oral hygiene agent Group 2 used conventional toothpaste and Group 3 practiced oil pulling with sesame oil Baseline and followup assessments included clinical indices Plaque Index PI Gingival Index GI and Bleeding on Probing BOP as well as oral microbiome sampling and patientreported outcome surveys on taste ease of use and side effects

The expected outcome is that Plantago major will demonstrate comparable or superior clinical efficacy to conventional methods with significant reductions in PI GI and BOP scores Additionally it is anticipated that patients will report fewer side effects and higher compliance with the herbal solution The intervention may also influence microbial diversity in a favorable direction without disrupting beneficial flora

By addressing existing research gaps in comparative efficacy and patient perception this study aims to validate Plantago major as a viable natural alternative to chemical mouthwashes and promote its role in integrative oral healthcare

研究设计

研究类型
Interventional
分配方式
Na
盲法
None

入排标准

年龄范围
18.00 Year(s) 至 70.00 Year(s)(—)
性别
All

入选标准

  • Participants aged from 18 to 70 years Individual with mild to moderate gingivitis or plaque index Ability to provide informed consent.

排除标准

  • Participants aged less than 18 and above 70 years Advanced periodontal diseases or other severe oral health issues Any known allergies to plantago or any components of the tincture Pregnant or breastfeeding individuals.

结局指标

主要结局

CHANGE IN THE MICROBIAL DIVERSITY AND LOAD

时间窗: CHANGE IN THE MICROBIAL DIVERSITY AND LOAD | REDUCTION IN PLAQUE INDEX GINGIVAL INDEX AND BLEEDING ON PROBING

REDUCTION IN PLAQUE INDEX GINGIVAL INDEX AND BLEEDING ON PROBING

时间窗: CHANGE IN THE MICROBIAL DIVERSITY AND LOAD | REDUCTION IN PLAQUE INDEX GINGIVAL INDEX AND BLEEDING ON PROBING

次要结局

未报告次要终点

研究者

发起方
Post Graduate Dissertation
申办方类型
Private medical college
责任方
Principal Investigator
主要研究者

Dr Bharath Kumar M

SARADA KRISHNA HOMOEOPATHIC MEDICAL COLLEGE

研究点 (1)

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