Surface-Electromyography in Patients with Acute Respiratory Distress Syndrome (ARDS)
Recruiting
- Conditions
- J80.0
- Registration Number
- DRKS00017138
- Lead Sponsor
- Charité Campus Virchow-Klinikum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 25
Inclusion Criteria
• ARDS due to pneumonia defined by Berlin Definition
• Age = 18 Years
• Admitted to a participating ICU at Charité Universitätsmedizin Berlin - Campus Virchow
Exclusion Criteria
• preexisting severe lung disease such aswie z.B.
o COPD (GOLD 3-4)
o pulmonary fibrosis
o cystic fibrosis
• unfavorable prognosis (death is expected within hours, in spite of maximal therapy)
• pregnant or breastfeeding patients
• patient is placed in a penal institution
• consent cannot be obtained by legal proxy
• patients advance directives exclude or argue against participation in a trial
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Ration of electrical (EMG) and mechanical (pressure/flow) signal of the respiratory muscles at the three following times of measurement:<br>• acute phase (within the first 48h after admission to a study-ICU)<br>• at the first reduction of sedation (Goal-RASS =-2) <br>• at the beginning of discontinuous Weaning (CPAP)
- Secondary Outcome Measures
Name Time Method • Ratio of sEMG of the diaphragm and other respiratory muscles <br>• maximal inspiratory and exspiratory flow<br>• transpulmonary pressure<br>• airway occlusion pressure<br>• respiratory fatigue during assisted ventilation <br>• diaphragmatic thickness (ultrasound)