Investigation of anti-histaminergic conditioning and expectation effects on the histamine prick-test

Phase 4

• Conditions: Placebo effects; T78.4; Allergy, unspecified

• Registration Number: DRKS00026099
• Lead Sponsor: niversitätsklinikum Essen (AöR), Klinik für Dermatologie, Venerologie und Allergologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-12-10
• Study Completion: 2023-02-03
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 101

Inclusion Criteria

Healthy participants aged >18 and <65 years, who consent to study participation in writing

Exclusion Criteria

- Pregnant or breast-feeding women
- Insufficient communication skills in the German language, dementia or functional analphabetism
- Lack of capacity or will to consent to the study
- Regular intake of anti-histaminergic medication
- Seasonal rhinoconjunctivits during the pollen season
- Skin diseases on the forearms that permit from evaluating the prick-test
- Known allergies against components of Cetirizin and/or the drink used for the conditioning procedure
- Known mastocytosis
- Lactose intolerance (medication contains lactose)

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparison of erythema size (in cm) and wheal size (in mm) at baseline and after three and five days of the experimental manipulation

Secondary Outcome Measures

Name	Time	Method
Perceived itch on a numeric rating scale (0-100) at baseline and after three and five days of the experimental manipulation