Comparing a diuretic vascular filling in the initial management of acute pulmonary embolism with right ventricular dysfunction normotensive

CHU de Nice0 sites0 target enrollmentJune 29, 2015

Overview

No summary available.

Registry

who.int

Start Date

June 29, 2015

End Date

TBD

Last Updated

5 years ago

Study Type

Interventional clinical trial of medicinal product

Sex

All

Sponsor

•older than 18 Patient
•Hospitalized in the first 24 hours of a serious EP normotensive formally diagnosed (by a chest CT)
•The serious nature without hypotension is defined by the presence of:
•\- From biological criteria: troponin and / or BNP positive
•\- In sonographic criteria: dilated right ventricle defined by echocardiography right over left ventricle ratio (VG)\> 0\.9 in apical 4\-chamber or 0\.7 in large parasternal axis and right ventricular systolic dysfunction (TAPSE \<16 mm and S 'pulsed TDI tricuspid \<10 cm / sec) or pulmonary arterial hypertension (PAH) Pulmonary Arterial Pressure with systolic (PAPs)\> 35 mmHg or paradoxical septum
•Informed consent signed
•Affiliation to social security
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1\.2 Adults (18\-64 years) yes

•Thrombolysis before inclusion
•State of cardiogenic shock defined as systolic BP \<90 mmHg or a drop of\> 40 mmHg in systolic BP for\> 15 minutes
•severe chronic renal impairment defined by clearance \<30 ml / min.
•pregnant or nursing woman (a pregnancy test will be performed for women of childbearing age and the results will be communicated to the patient by a doctor of his choice)
•Most People under guardianship
•hospitalized without their consent and not protected by law No
•Private person of liberty
•Residence time of more than 24 hours in another department after the positive diagnosis of pulmonary embolism