Pulsatility in cerebral perforating arteries in patients with lacunar infarction or deep hemorrhage, an explorative 7T MRI study.

Completed

• Conditions: deep intracerebral hemorrhage/hemorrhagde in the deep structures of the brain.; lacunar infarction/small deep infarction; 10007963

• Registration Number: NL-OMON44727
• Lead Sponsor: Divisie Beeld, afdeling Radiologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 55

Inclusion Criteria

Lacunar infarction group:
- Clinical lacunar stroke confirmed by imaging, in the last 5 years.
Deep ICH group:
- Deep spontaneous ICH, compatible with so-called hypertensive hemorrhage or ICH due to SVD, confirmed by imaging, in the last 5 years.
Healthy control group:
- No history of stroke, transient ischemic attack or cognitive impairment.

Exclusion Criteria

All groups:
- WHO performance status score * 2. (independent mobility and living)
- Currently hospitalized.
- MRI contraindications per clinical practice, such as (possible) pregnancy and metal or electronic implants not compatible with (7T) MRI.
Control group:
- When study images for a control subject as a chance finding show confluent white matter hyperintensities (Fazekas scale > 2), lacunes or ICH the control will be excluded and replaced.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Difference in pulsatility of cerebral perforating arteries between patients and<br /><br>healthy controls.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>N.A.</p><br>