A randomized controlled clinical trial to compare the efficacy of standard dose of steroids vs reduced dose in children with nephrotic syndrome
Phase 1
- Conditions
- Health Condition 1: null- Children with Steroid sensitive Nephrotic Syndrome with infrequent relapses
- Registration Number
- CTRI/2018/05/013634
- Lead Sponsor
- Suprita Kalra
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Other (Terminated)
- Sex
- Not specified
- Target Recruitment
- 27
Inclusion Criteria
all children with idiopathic nephrotic syndrome on stable immunosuppression(either long term alternate day steroids,levamisole or mycophenolate mofetil) or on no immunosuppresion for last 6 months with infrequent relapses defined as less than 2 relapses in last 6 months
Exclusion Criteria
•children started on a steroid sparing agent in last 6 months due to frequent relapses or steroid dependence,
•Children with steroid resistant nephrotic syndrome
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Proportion of frequent relapsers on the reduced dose regime as compared to standard regime <br/ ><br>Number of relapses in children in whom steroid dose is reduced to 1mg/kg alternate day for 4 weeks instead of the standard 1.5 mg/kg/day alternate day in 6 months <br/ ><br>Timepoint: 6 months follow up of each child since enrollment
- Secondary Outcome Measures
Name Time Method <br/ ><br>Â Cumulative steroid dose in two groups for 6 months <br/ ><br>Timepoint: 6 months follow up of each child since enrollment