Food Preference Following Bariatric Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 34
- 试验地点
- 1
- 主要终点
- Total Food Intake (Lunch Buffet) at 24 Months
研究概览
简要总结
Roux-en-Y gastric bypass (RYGB) decreases appetite, caloric intake, glycemia, and body weight, all of which are maintained long term.It is controversial whether, after RYGB, patients choose to eat less high fat and sugary foods in favor of lower energy dense alternatives. Therefore the proposition to use direct measures in humans after RYGB to test the hypothesis that the selection and intake of foods varying in fat content and glycemic index, as well as the pattern of ingestion within and across meals, changes in a manner that leads to beneficial outcomes on body weight.
详细描述
Roux-en-Y gastric bypass (RYGB) decreases appetite, caloric intake, glycemia, and body weight, all of which are maintained long term.It is controversial whether, after RYGB, patients choose to eat less high fat and sugary foods in favor of lower energy dense alternatives. If true, this could conceivably contribute to improved glycemia and body weight. Disparities among studies on food selection and intake are likely due to the almost complete reliance on self-reported food intake which is vulnerable to inaccuracy.This controversy can best be resolved by complementing existing findings with direct measures of target behaviour in humans. Therefore the proposition to use direct measures in humans after RYGB to test the hypothesis that the selection and intake of foods varying in fat content and glycemic index, as well as the pattern of ingestion within and across meals, changes in a manner that leads to beneficial outcomes on body weight.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Surgical and non-surgical groups:
- •A) Bariatric surgery B) Controls with no history of bariatric surgery
- •Independently mobile
- •Capacity to consent to participate
- •>18 years of age
排除标准
- •Pre-operatively: significant dysphagia, gastric outlet obstruction or anything that prevents subjects from eating a meal.
- •Post-operatively: significant and persistent surgical complications or anything that prevents subjects from eating a meal.
- •Systemic or gastrointestinal condition which may affect food intake or preference, including:
- •i) pregnancy or ii) breast feeding.
- •Active and significant psychiatric illness including substance misuse
- •Significant cognitive or communication issues
- •Medications with documented effect on food intake or food preference
- •History of significant food allergy and certain dietary restrictions
- •History of liver disease or pancreatitis
- •History of bradyarrythmia or congestive cardiac failure group)
- •Use of medications with potential serious interactions with Octreotide
结局指标
主要结局
Total Food Intake (Lunch Buffet) at 24 Months
时间窗: 24 months
Determine the effect of RYGB on total food intake from an ad libitum lunch buffet
Change in Absolute Intake of Carbohydrates
时间窗: 24 months
Determine the effect of RYGB on food preferences by measuring the absolute i.e. total intake of carbohydrates from an ad libitum lunch buffet
Change in Absolute Intake of Fat
时间窗: 24 months
Determine the effect of RYGB on food preferences by measuring the absolute i.e. total intake of fat from an ad libitum lunch buffet
Change in Absolute Intake of Protein
时间窗: 24 months
Determine the effect of RYGB on food preferences by measuring the absolute i.e. total intake of protein from an ad libitum lunch buffet
Change in Absolute Intake of Sugar
时间窗: 24 months
Determine the effect of RYGB on food preferences by measuring the absolute i.e. total intake of sugar from an ad libitum lunch buffet
次要结局
未报告次要终点
研究者
Carel Le Roux
Reader in Investigative Science
Imperial College London