Food Preference Following Bariatric Surgery

Completed

• Conditions: Obesity
• Interventions: Behavioral: Food Preference

• Registration Number: NCT03363581
• Lead Sponsor: Imperial College London

Brief Summary

Roux-en-Y gastric bypass (RYGB) decreases appetite, caloric intake, glycemia, and body weight, all of which are maintained long term.It is controversial whether, after RYGB, patients choose to eat less high fat and sugary foods in favor of lower energy dense alternatives. Therefore the proposition to use direct measures in humans after RYGB to test the hypothesis that the selection and intake of foods varying in fat content and glycemic index, as well as the pattern of ingestion within and across meals, changes in a manner that leads to beneficial outcomes on body weight.

Detailed Description

Roux-en-Y gastric bypass (RYGB) decreases appetite, caloric intake, glycemia, and body weight, all of which are maintained long term.It is controversial whether, after RYGB, patients choose to eat less high fat and sugary foods in favor of lower energy dense alternatives. If true, this could conceivably contribute to improved glycemia and body weight. Disparities among studies on food selection and intake are likely due to the almost complete reliance on self-reported food intake which is vulnerable to inaccuracy.This controversy can best be resolved by complementing existing findings with direct measures of target behaviour in humans. Therefore the proposition to use direct measures in humans after RYGB to test the hypothesis that the selection and intake of foods varying in fat content and glycemic index, as well as the pattern of ingestion within and across meals, changes in a manner that leads to beneficial outcomes on body weight.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2017-08-09
• Study First Submitted QC: 2017-12-05
• Study First Posted: 2017-12-06
• Study Start: 2017-12-15
• Primary Completion: 2021-09-30
• Study Completion: 2021-09-30
• Results First Submitted: 2021-11-12
• Status Verified: 2022-10
• Results First Submitted QC: 2022-10-03
• Last Update Submitted: 2022-10-03
• Results First Posted: 2023-08-08
• Last Update Posted: 2023-08-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

1. Surgical and non-surgical groups:

   A) Bariatric surgery B) Controls with no history of bariatric surgery

2. Independently mobile

3. Capacity to consent to participate

4. >18 years of age

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Exclusion Criteria

1. Pre-operatively: significant dysphagia, gastric outlet obstruction or anything that prevents subjects from eating a meal.

2. Post-operatively: significant and persistent surgical complications or anything that prevents subjects from eating a meal.

3. Systemic or gastrointestinal condition which may affect food intake or preference, including:

   i) pregnancy or ii) breast feeding.

4. Active and significant psychiatric illness including substance misuse

5. Significant cognitive or communication issues

6. Medications with documented effect on food intake or food preference

7. History of significant food allergy and certain dietary restrictions

8. History of liver disease or pancreatitis

9. History of bradyarrythmia or congestive cardiac failure group)

10. Use of medications with potential serious interactions with Octreotide

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Gastric bypass	Food Preference	Obese patients due to undergo gastric bypass surgery
Control	Food Preference	Healthy free-living individuals

Primary Outcome Measures

Name	Time	Method
Total Food Intake (Lunch Buffet) at 24 Months	24 months	Determine the effect of RYGB on total food intake from an ad libitum lunch buffet
Change in Absolute Intake of Carbohydrates	24 months	Determine the effect of RYGB on food preferences by measuring the absolute i.e. total intake of carbohydrates from an ad libitum lunch buffet
Change in Absolute Intake of Fat	24 months	Determine the effect of RYGB on food preferences by measuring the absolute i.e. total intake of fat from an ad libitum lunch buffet
Change in Absolute Intake of Protein	24 months	Determine the effect of RYGB on food preferences by measuring the absolute i.e. total intake of protein from an ad libitum lunch buffet
Change in Absolute Intake of Sugar	24 months	Determine the effect of RYGB on food preferences by measuring the absolute i.e. total intake of sugar from an ad libitum lunch buffet

Trial Locations

Locations (1)

University College Dublin; 🇮🇪 Dublin, Ireland