NL-OMON38270已完成2 期
Effects of Sildenafil on pulmonary artery pressure in patients with heart failure with preserved ejection fraction and pulmonary hypertension - Sildenafil in HFpEF and PH
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 52
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •PH secondary to HFpEF defined as mean PAP larger 25 mmHg, wedge larger 15, LVEF larger 45
- •NYHA II-IV
排除标准
- •other cause of PH
- •severe noncardiac limitation to exercise
- •coronary ischemia or recent myocardial infarction (<6 months)
- •hypotension , RR< 90/50
- •ongoing nitrate therapy
- •significant left sided valve disease
- •severe liver dysfunction
- •unable to read and comprehend Dutch language
研究者
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Effects of Sildenafil on pulmonary artery pressure in patients with heart failure with preserved ejection fraction and pulmonary hypertension - Sildenafil in HFpEF and PHThe condition to be investigated is isolated left heart failure , also called heart failure with preserved ejection fraction ( HFpEF) with pulmonary hypertension. HFpEF is a clinical syndrome with severe symptoms and high mortality. The presence of PH in HFpEF is associated with increased mortality . Nevertheless there is no evidence based medical treatment regiment for this condition.EUCTR2010-020153-14-NLniversity Medical Center Groningen52
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