The impact of norepinephrine on top-down and bottom-up neural processing

Completed

• Conditions: wetenschappelijk onderzoek met gezonde vrijwilligers; healthy

• Registration Number: NL-OMON40584
• Lead Sponsor: niversiteit Leiden

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

Healthy adult subjects with no history of neurological disorder/disease and no counter-indications to 3 Tesla MRI or to atomoxetine, and no personal relationship with the researchers will be included in this study. All participants will be right-handed native Dutch speakers with normal vision or contact lenses.

Exclusion Criteria

Potential participants will be prescreened for contra-indications for 3 Tesla fMRI and atomoxetine, which include metal implants, heart arrhythmia, claustrophobia, glaucoma, hypertension and use of anti-depressants or psychotropic medication and possible pregnancy (in adult females). They will additionally be prescreened for head trauma, premature birth, learning disabilities, and history of neurological or psychiatric illness. Finally, left-handed individuals will be excluded from the study because some left-handers have substantially different brain organization relative to right-handers.

Study & Design

• Study Type: Interventional
• Study Design: Not specified