The role of the norepinephrine system in emotion, vigilance and error processing.
Completed
- Conditions
- focus op het gezonde breinniet van toepassing
- Registration Number
- NL-OMON32686
- Lead Sponsor
- niversiteit Leiden
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Adult subjects between the ages 18 and 30 with no history of neurological disorder/disease and normal blood pressure and heart rate will be included in this study. All participants will be right-handed native Dutch speakers.
Exclusion Criteria
Low blood pressure, bradycardia, cardiac arrhythmia, severe pulmonary conditions, head trauma, learning disabilities, and history of neurological or psychiatric illness and/or use of (psychotropic) medication. Further, subjects with Dutch as a second language and left-handed individuals will be excluded.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter is the EEG measurement. The endpoint is the effect of<br /><br>propranolol on the EEG signal. We hypothesize that propranolol will decrease<br /><br>the amplitude of the different components of the EEG signal that we<br /><br>investigate.</p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary study parameter is subsequent memory (% correctly recognized<br /><br>stimuli after the 2 week interval). The endpoint is the effect of propranolol<br /><br>on subsequent memory. We hypothesize that subsequent memory will be better for<br /><br>emotional than for neutral stimuli (higher % correctly recognized stimuli after<br /><br>the 2 week interval) and that this difference will decrease because of<br /><br>propranolol.</p><br>