The effects of phenylephrine and norepinephrine on maternal and umbilical oxidative stress level during cesarean delivery under spinal anesthesia

Phase 4

• Conditions: The effects of two vasopressors (phenylephrine and norepinephrine) on oxidative stress level during elective cesarean section performed in spinal anesthesia.; O82; Single delivery by caesarean section

• Registration Number: DRKS00017259
• Lead Sponsor: Clinic of Gynaecology and Obstetrics University Clinical centre Nis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-05-10
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Female
• Target Recruitment: 40

Inclusion Criteria

Patients ASA I and II status, scheduled for elective caesarean section in spinal anesthesia who have given written informed consent.

Exclusion Criteria

Exclusion criteria include contraindications and patients’ refusal of spinal anesthesia, known cardiac, respiratory, neurologic, renal, endocrine, psychiatric disorders, history of drug or alcohol abuse, morbid obesity, preeclampsia, active labor, known fetal congenital abnormalities or signs of fetal compromise.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Our primary goal is to compare the effects of phenylephrine and norepinephrine on maternal and umbilical oxidative stress and therefore conclude which of the used drugs has a better effect.

Secondary Outcome Measures

Name	Time	Method
Our secondary goal is to compare the effects of phenylephrine and norepinephrine on maternal hemodynamics, on the occurrence of nausea and vomiting, on neonatal Apgar score and umbilical gas analysis.