NL-OMON39350
Completed
Not Applicable
The effects of consumption of vitamin E or lipoic acid on serum oxyphytosterol concentrations in subjects with impaired glucose tolerance or type II diabetes - Antioxidants and oxyphytosterol concentrations
Medisch Universitair Ziekenhuis Maastricht0 sites20 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- 10013317
- Sponsor
- Medisch Universitair Ziekenhuis Maastricht
- Enrollment
- 20
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Aged between 18 and 75 years
- •Body Mass Index (BMI) between 20\-35 kg/m2
- •Mean serum total cholesterol \<8\.0 mmol/L
- •Mean serum triacylglycerol \<3\.0 mmol/L
- •Diagnosed with diabetes mellitus type 2 on a clinical basis or impaired glucose tolerance (defined as blood glucose \>7\.8 mmol/l and \<11\.0 mmol/L, two hours after ingesting 75 gram glucose in 150 ml water)
Exclusion Criteria
- •Unstable body weight (weight gain or loss \> 3 kg in the past two months)
- •Active cardiovascular diseases like congestive heart failure or recent (\<6 months) event (acute myocardial infarction, cerebral vascular incident)
- •Severe medical conditions that might interfere with the study such as epilepsy, asthma, chronic obstructive pulmonary disease, inflammatory bowel disease and rheumatoid arthritis
- •Use of medication such as corticosteroids, diuretics or lipid lowering therapy
- •Use of insulin therapy
- •Abuse of drugs or alcohol (\>21 units per week)
- •Not willing to stop the consumption of vitamin supplements, containing lipoic acid and/or vitamin E, 1 month before the start of the study (wash\-in period)
- •Use of an investigational product within another biomedical study within the previous month
- •Pregnant or breast\-feeding women
- •Current smoker
Outcomes
Primary Outcomes
Not specified
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