Gene Expression Profiles in Predicting Survival of Patients With Head and Neck Cancer
- Conditions
- Head and Neck Cancer
- Registration Number
- NCT00897052
- Lead Sponsor
- Vanderbilt-Ingram Cancer Center
- Brief Summary
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict survival of patients with head and neck cancer.
PURPOSE: This laboratory study is assessing gene expression profiles in predicting survival of patients with head and neck cancer.
- Detailed Description
OBJECTIVES:
* Identify gene expression profiles associated with survival by DNA microarray assay analysis using RNA from formalin-fixed paraffin-embedded tissue samples from patients with squamous cell carcinoma of the head and neck treated on clinical trial RTOG-9501.
OUTLINE: Formalin-fixed paraffin-embedded tissue samples are analyzed by DNA microarray analysis for gene expression profiling.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 29
-
Diagnosis of squamous cell carcinoma of the head and neck, including 1 of the following sites:
- Hypopharynx
- Larynx
- Oral cavity
- Oropharynx
-
Stage II-IV disease
-
Must have received treatment on clinical trial RTOG-9501
-
Formalin-fixed paraffin-embedded tissue samples available
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Identification of gene expression profiles used to predict survival as assessed by DNA microarray analysis at time of surgical resection
- Secondary Outcome Measures
Name Time Method