Effects of SIT Combined with Remote Ischemic Preconditioning on Vascular Function in Young Women with Masked Obesity

Not Applicable

Completed

• Conditions: Vascular Function

• Registration Number: NCT06664281
• Lead Sponsor: Beijing Sport University

Brief Summary

Comparison of the effects of combined Sprint Interval Training (SIT) with Remote Ischemic Preconditioning (RIPC) and SIT on vascular function in young women with masked obesity.

Detailed Description

This is a randomized clinical trial of single-blind with 3 arms (control group, SIT group and SIT with RIPC group), in which a pre-treatment-posttest design has been used.

Study Timeline

• Study Start: 2023-02-28
• Primary Completion: 2023-10-30
• Study Completion: 2023-12-30
• Status Verified: 2024-09
• Study First Submitted: 2024-10-24
• Study First Submitted QC: 2024-10-28
• Last Update Submitted: 2024-10-28
• Study First Posted: 2024-10-29
• Last Update Posted: 2024-10-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 44

Inclusion Criteria

• Females aged between 18 and 30 years;
• BMI within the normal range (18.5～24.9 kg/m²), BF% > 30%;
• Participants with no clinically diagnosed contraindications for exercise, in good health, and not engaged in regular exercise, as determined by the health and physical activity questionnaire (based on the American College of Sports Medicine's guidelines for exercise testing and prescription).

Exclusion Criteria

• History of cardiovascular diseases, including coronary heart disease, stroke, or peripheral arterial disease diagnosed through vascular imaging techniques;
• Currently participating in other intervention studies, including dietary, nutritional, or psychological education programs;
• Those with regular professional training;
• Musculoskeletal disorders that make long-term exercise interventions unsuitable.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Intima-Media Thickness (IMT)	8 weeks	Changes in Intima media thickness before and after intervention.
Flow-Mediated Dilation (FMD)	8 weeks	Changes in Flow-mediated dilation before and after Intervention. Brachial artery flow-mediated dilation (FMD) was measured by the UNEXEF high-resolution ultrasound vascular endothelial function analyzer.

Secondary Outcome Measures

Name	Time	Method
Body Composition Indicator	8 weeks	Changes in Body composition indicators before and after Intervention. Including body fat percentage (BF%).
Human Morphometric i Indicators	8 weeks	Changes in Human morphometric indicators before and after Intervention. Including height, weight, waist circumference, hip circumference, and body mass index (BMI). BMI was calculated based on the measured height and weight using the formula: BMI = weight/height² (kg/m²).
Blood Pressure (BP)	8 weeks	Changes in blood pressure before and after intervention. Including systolic and diastolic blood pressure.
Nitric Oxide (NO)	8 weeks	Changes in concentration of nitric oxide before and after Intervention.
Maximum Oxygen Uptake (VO2max)	8 weeks	Changes in maximum oxygen uptake before and after Intervention.

Trial Locations

Locations (1)

School of Sports Medicine and Rehabilitation, Beijing Sport University; 🇨🇳 Beijing, China