Effects of Cranberry Juice on Risk Factors for Cardiovascular Disease

Completed

Brief Summary: This study is being done to determine if the use of double strength cranberry juice in daily diet will improve endothelial function.

Detailed Description: Study participants will be randomized assigned to drink either placebo (a drink that looks and tastes like cranberry juice, but does not contain cranberry juice) or a double strength Ocean Spray light cranberry juice cocktail for four months.

Recruitment & Eligibility

Inclusion Criteria

Subjects over the age of 18 years old with known or suspected cardiovascular disease including documented CAD by cardiac catheterization, and multiple cardiovascular risk factors will be included, regardless of severity of endothelial dysfunction or previous history of cardiovascular events.
Subjects with no known history of cardiac disease will also be eligible to participate.
Subjects must demonstrate endothelial dysfunction via the RH-PAT test (an RH-PAT score of less than 2.0) to continue participating in this study.

Exclusion Criteria

Patients will be excluded if they have confounding factors including, but not limited to, history of renal or liver failure, or relevant food allergies (cranberries, etc.).

Primary Outcome Measures

Name	Time	Method
The current study was designed to test the hypothesis that the chronic administration of supplementation with double-strength cranberry juice will improve peripheral endothelial dysfunction.	baseline and 4 months post

Secondary Outcome Measures

Name	Time	Method
The current study was also designed to test the acute effect of double-strength cranberry juice on endothelial function.	45 mins post consumption

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