The Effect of Ingestion of Foods on the Plasma Glucose and Insulin Response in Subjects With Type 2 Diabetes: Protein, Amino Acids & Insulin & Glucagon Secretion in Humans
试验速览
- 阶段
- 不适用
- 状态
- 暂停
- 发起方
- 入组人数
- 300
- 试验地点
- 2
- 主要终点
- Change in blood glucose concentration
研究概览
简要总结
The purpose of this study is to determine the effect of various foods and/or food substances such as fats or proteins on the blood glucose and insulin concentrations in people with and without type 2 diabetes.
详细描述
Various foods or food substances are given as a test meal. The metabolic response is determined at various times after the administration of the meal (e.g. blood glucose, and other hormones and metabolites).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subjects with or without type 2 diabetes
- •C-Peptide > 1.5 ng/ml
- •Able to come to the Minneapolis VA Medical Center on several occasions over 2-4 weeks
排除标准
- •Body mass index > 40
- •hematologic abnormalities
- •liver disease
- •kidney disease
- •congestive heart failure
- •life threatening malignancies
结局指标
主要结局
Change in blood glucose concentration
时间窗: several time points after ingestion of test substance
Test substances will be given at 0800 hr and blood drawn at several time points up to 5 hours after the meal.
次要结局
- Change in serum insulin concentration(Several time points after ingestion of test substance)
研究者
Frank Q. Nuttall, MD, PhD
Section of Endocrinology, Metabolism & Nutrition, Professor of Medicine
Minneapolis Veterans Affairs Medical Center