Gastro-oesophageal Reflux in Oligosymptomatic Patients With Dental Erosion
- Conditions
- Dental ErosionGastroesophageal Reflux
- Registration Number
- NCT02087345
- Lead Sponsor
- Brain-Gut Research Group
- Brief Summary
Dental erosions, the chemical dissolution of enamel without bacterial involvement, are considered to be an established complication of gastroesophageal reflux disease (GERD) by the Montreal global consensus statement. Given the high prevalence of dental erosions and the absence of any pH-impedance data or medical management guidelines for GERD-associated dental erosions, reflux characteristics will be characterized using questionnaires, endoscopy and esophageal pH-impedance testing, in successive patients dental erosions referred by dentists for evaluation of GERD. For assessment of the role of additional factors besides H+ activity in the refluxate, a sample of gastric juice will be aspirated during endoscopy and frozen for analysis of pepsin and other proteases. Prognostic factors for progression of dental erosions will be determined by repeating the evaluation after chronic dosing with esomeprazole 20mg twice-daily, which is prescribed to all patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 500
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The % of time with pH<4 and 5.5 during 24-hour pH-impedance 1 year
- Secondary Outcome Measures
Name Time Method The number of acidic and weakly acidic reflux episodes during 24-hour pH-impedance 1 year
Trial Locations
- Locations (1)
Gastroenterology Group Practice
🇨đź‡Bern, Switzerland