Efficacy of inhaled rhDNase for acute asthma in childhood.

Completed

• Conditions: acute childhood asthma

• Registration Number: NL-OMON29109
• Lead Sponsor: Erasmus MC, Sophia Children's Hospital

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

Children, aged 2-18 years, with acute asthma who require at least two doses of bronchodilators at the emergency department.

Exclusion Criteria

1. Dyspnoea due to other causes than asthma;

2. Patients with a concurrent chronic pulmonary disease, such as CF, BPD;

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Improvement in asthma score 1 hour after intervention.

Secondary Outcome Measures

Name	Time	Method
1. Need for hospital admission;<br /><br>2. Duration of hosptial admission;<br /><br>3. Asthma score at 2,6,12 and 24 hours after intervention;<br /><br>4. Heart rate, respiratory rate and oxygen saturation;<br /> <br>5. Need for additional oxygen;<br /><br>6. Number of bronchodilators;<br /><br>7. Doctor’s visit or readmission and use of rescue bronchodilator aerosol therapy following 72 hours after discharge from EMD;<br /><br>8. Cost-consequence analysis.