Evaluation of Heart Status in Patients of Beta Thalassemia Using Echocardiogram

Recruiting

• Conditions: Beta Thalassemia
• Interventions: Diagnostic Test: Echocardiogram and Hematological Analysis

• Registration Number: NCT04929574
• Lead Sponsor: Nanfang Hospital, Southern Medical University

Brief Summary

Heart failure from myocardial iron deposition is a severe complication for patients with transfusion-dependent beta thalassemia . Increased cardiac iron content impacts the contractility of cardiomyocytes and can also lead to myocarditis, pericarditis, and arrhythmias. The severity of cardiac dysfunction depends on the amount of iron deposited in the myocardium.Echocardiogram is used as noninvasive method to observe heart status. The objective of this study is to evaluate the heart status in patients of Beta Thalassemia from southern China.

Detailed Description

Not available

Study Timeline

• Status Verified: 2021-05
• Study First Submitted: 2021-06-03
• Study First Submitted QC: 2021-06-16
• Last Update Submitted: 2021-06-16
• Study First Posted: 2021-06-18
• Last Update Posted: 2021-06-18
• Study Start: 2021-07-01
• Primary Completion: 2024-07-01
• Study Completion: 2025-12-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1200

Inclusion Criteria

• Diagnosed with beta-thalassemia

Exclusion Criteria

• Iron deficiency anemia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
beta thalassemia patients	Echocardiogram and Hematological Analysis	-

Primary Outcome Measures

Name	Time	Method
Echocardiogram	3 years	Evaluation of heart function in beta thalassemia patients by left ventricular fraction shortening

Trial Locations

Locations (1)

Southern Medical University; 🇨🇳 Guangzhou, Guangdong, China