MRI Screening for Patients With Myelodysplastic Syndrome (MDS), Who Have Received Multiple Red Blood Cell Transfusions
Not Applicable
Completed
- Conditions
- Myelodysplastic Syndrome (MDS)
- Interventions
- Other: T2* Cardiac and Liver MRI
- Registration Number
- NCT00749372
- Lead Sponsor
- Weill Medical College of Cornell University
- Brief Summary
A known risk of red blood cell transfusions is that it puts excess iron into the patient's body. Researchers are continually seeking the most effective method of measuring iron concentration. The purpose of this study is to determine how much iron has been deposited in a patient's heart and liver as a result of having received red blood cell transfusions using magnetic resonance imaging (MRI).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
- Male or Female patients will need documentation of diagnosis of Myelodysplastic Syndrome by previous bone marrow exam
- Male or female patients with MDS who have received at least 50 units of Red Blood Cell Transfusions.
- Serum ferritin > 1,000
- Written informed consent by the patient.
Exclusion Criteria
- Contraindication to MRI, including cardiac pacemaker, brain aneurysm clip, implanted neurostimulator, insulin pump, cochlear implant, metal slivers in the eyes, intrauterine device or any other MRI incompatible metal implants or intractable claustrophobia.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description 1 T2* Cardiac and Liver MRI Patients who meet eligibility will be sent for radiographic imaging to include T2\* cardiac and liver MRI to ascertain quantification of organ-specific iron concentrations as well as cardiac left ventricular ejection fraction.
- Primary Outcome Measures
Name Time Method To evaluate the incidence of clinically significant cardiac iron overload in heavily transfused MDS patients using T2* MRI. A single T2* MRI will be performed on eligible patients.
- Secondary Outcome Measures
Name Time Method Evaluate left ventricular ejection fraction as assessed by T2* MRI. A single T2* MRI will be performed on eligible patients. Evaluate liver iron concentration as assessed by R2* MRI A single T2* MRI will be performed on eligible patients.
Trial Locations
- Locations (1)
Weill Medical College of Cornell University
🇺🇸New York, New York, United States