Reserch on the effect of losartan on diastolic heart failure patients with hyperuricemia
Not Applicable
- Conditions
- Elderly diastolic heart failure patients with hyperuricemia
- Registration Number
- JPRN-UMIN000007846
- Lead Sponsor
- osartan study group
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Not provided
Exclusion Criteria
Medication for high uric acid Creatinine level 2.0mg/dl or over Serum potassium level 5.0meq/l or over Clinical history of Gouty attack Undertreatment of angiotensin receptor blocker NYHA4
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change of uric acid level
- Secondary Outcome Measures
Name Time Method 1.NYHA 2.Rho-kinase activity of circulating leukocyte 3.cyclophilin A, 8-isoproatane 4.pentraxin3, Hs-CRP 5.NT-proBNP 6.renin activity, aldsterone activity 7.echocardiography: ejection fraction, diastolic function(E/A,E/e') 8.flow mediated dilation 9.urinary albumin-to-creatinine ratio 10.Hospitalization for worsenig heart failure,all cause death