Effect of Losartan/HCTZ on diastolic function in patients with hypertension 2 Comparison with ARB/CCB combined therapy

Not Applicable

Recruiting

• Conditions: Hypertension patients with left ventricular diastolic dysfunction

• Registration Number: JPRN-UMIN000004080
• Lead Sponsor: Diastolic Dysfunction Study Group

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-09-01
• Study Completion: 2012-12-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

Not provided

Exclusion Criteria

Insufficiently controlled hypertension DBP more than 110mmHg Secondary hypertension Diabetes mellitus patient under insulin treatment Onset of myocardial infarction or stroke within 6 months before recruiting Concurrent hepatic dysfunction GPT more than 3 times the upper limit of normal values Renal dysfunction sCr more than 2.0 mg/dL Gout or hyperuricemia uric acid more than 8.0 mg/dL Heart failure with NYHA 3 or more AF undergo echocardiography Valvular disease Malignant tumor and/or poor prognosis severe disease Women who are pregnant, enable to be pregnant, or are breastfeeding Concurrent treatment with diuretics and/or CCB Hypersensitivity or allergy to losartan, HCTZ and amlodipine Hypersensitivity or allergy to thiazide and other analogs Patients who are determined by the investigators to be unsuitable

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in e' and e'/E