Incidence, Risk Factors, Predictors and Survival for Neurological Complications After Liver Transplantation

Completed

• Conditions: Liver Transplant; Complications; Neurologic Complication; Postoperative Complications

• Registration Number: NCT04188717
• Lead Sponsor: Institute of Liver and Biliary Sciences, India

Brief Summary

Liver transplantation is the definitive treatment in patients with chronic liver disease. Neurological complications (NC) occur commonly after liver transplantation. The investigators aim to evaluate the incidence, risk factors and predictors of neurological complications in both living donor and deceased donor transplantation done in the hospital. Between January 2011 to December 2016, 253 liver transplant recipients were recruited for this study. The investigators recorded the incidence of neurological complications, their median time of onset, their relationship with etiology of chronic liver disease, and the risk factors for the complications. The investigators also studied the relationship of neurological complications with duration of hospital and ICU stay, and survival. Using multivariate forward regression analysis , the investigators developed a scoring system for prediction of neurological complications in liver transplantation.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-01-01
• Primary Completion: 2016-12-31
• Study Completion: 2017-01-01
• Status Verified: 2019-11
• Study First Submitted: 2019-11-28
• Study First Submitted QC: 2019-12-05
• Study First Posted: 2019-12-06
• Last Update Submitted: 2019-12-07
• Last Update Posted: 2019-12-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 253

Inclusion Criteria

• patients undergoing liver transplant surgery
• 18-65 years

Exclusion Criteria

• pregnant patients
• Acute Liver Failure, Acute on Chronic Liver Failure

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mortality	90 days	mortality due to any cause
Neurological complications	90 days	type of neurological complication