A study to compare thepostoperative analgesic efficacy of dexamethasone as an adjuvant to ropivacaine in incision site infiltration in patients undergoing elective supratentorial craniotomy
Phase 1
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2023/08/056100
- Lead Sponsor
- SMS Medical College and attached Hospitals
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Patients given informed and written consent
2. 20 - 50 years of age of either gender
3. ASA physical status of I-II
4. Scheduled for elective supratentorial tumour craniotomy under general
anaesthesia
5. Patients in whom surgeon anticipates uneventful extubation and return of
consciousness, orientation as well as cooperation after extubation so that patient may correctly express the degree of pain.
Exclusion Criteria
1.Patients with history of previous craniotomy ,psychiatric disorders,epilepsy or chronic headaches
2.BMI <15 or >35
3. Allergic to opioids,dexamethasone or ropivacaine
4.history of excessive alcohol or drug abuse
5.preoperative GCS <15
6. Peri-incisional infection
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. To assess & compare mean rescue analgesic consumption (diclofenac ) in between study groups. <br/ ><br>2. To assess & compare mean time to require first rescue analgesic between study groups. <br/ ><br>3. To assess and compare mean NRS (Numerical Rating Scale)value in between study groups.Timepoint: 0 <br/ ><br>6 <br/ ><br>12 <br/ ><br>24 hours
- Secondary Outcome Measures
Name Time Method 1.To assess & compare mean PONV scores at 0,6,12,24 hrs <br/ ><br>2.To assess and compare PSS scores at 24 hrs <br/ ><br>3.To assess and compare mean haemodynamic parameters at 0,6,12,24 hrsTimepoint: 0 <br/ ><br>6 <br/ ><br>12 <br/ ><br>24 hours