The haemodynamic effect of sildenafil in mechanically ventilated patients with secondary pulmonary hypertension and ensuing right ventricular failure necessitating the administration of dobutamine

Completed

• Conditions: Secondary pulmonary hypertension, right ventricular failure; Circulatory System; Pulmonary hypertension

• Registration Number: ISRCTN35752874
• Lead Sponsor: General State Hospital of Athens (Greece)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-09-23
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

1. Secondary pulmonary arterial hypertension (PAH) associated with disorders of the respiratory system or hypoxemia (WHO Group III PAH). PAH was documented by the following echocardiographic criteria:
1.1. Increased systolic pulmonary artery pressure greater than 37 mmHg (using the Doppler-derived tricuspid regurgitation velocity)
1.2. Dilatation of the right cardiac chambers
1.3. Hypertrophy of the RV free wall
1.4. Left sided transposition of the interventricular septum and D-shape derangement of the left ventricle
2. Required mechanical ventilation
3. Admitted to the intensive care unit (ICU) from January 2007 to April 2010
4. Decreased cardiac output necessitating the administration of inotropes. Cardiac output was estimated by Doppler echocardiography at the aortic annular plane.
5. Aged 48 - 65 years, either sex

Exclusion Criteria

1. Secondary PAH due to left ventricular (LV) failure, and/or other causes of secondary PAH
2. Patients exhibited, upon admission, acute respiratory distress syndrome (ARDS) and septic shock
3. Hemodynamically unstable, necessitating administration of any other vasoactive medication during the study period

Study & Design

• Study Type: Interventional
• Study Design: Not specified