Computer based cognitive flexibility training after stroke

Completed

Conditions: cerebrovascular accident
Stroke
10007963

Registration Number: NL-OMON40530

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 160

Inclusion Criteria

1) Suffered from stroke and referred to rehabilitation; 2) Presence of cognitive dysfunction due to stroke; 3) Age between 30 and 80 years; 4) Daily access to computer with internet connection and able to use mouse; 5) lnformed consent for study participation.

Exclusion Criteria

1) Any disease other than stroke which results in severe cognitive impairments 2) Severe psychological, psychiatric, or somatic comorbidity which could strongly influence the performance on the neuropsychological assessment and training possibilities 3) Mentally (Telephone Interview Cognitive Status (TICS) score < 26) and physically (medically unstable) not fit enough to complete training protocol. 4) Aphasia, neglect, paresis or paralysis of the preferred hand, colorblindness, invalidating vision or hearing problems, or severe computer fear disabling the participants to fully complete the neuropsychological assessment and training

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome is executive functioning as measured by several<br /><br>neuropsychological tasks (Fluency, Tower of London, Trail Making Test,<br /><br>letter-number sequencing)<br /><br><br /><br>See protocol for a description of these tasks. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1) Cognitive flexibility as measured by switchcost (reactietimes op<br /><br>switchtrials compared to reaction times on non -switchtrials) on the switch<br /><br>task.<br /><br>2) Cognitive functioning as measured by several neuropsychological tasks and<br /><br>computer tasks (see protocol)<br /><br>3) Training improvement<br /><br>4) Subjective cognitive functioning and functioning in daily life as measured<br /><br>by: dysexecutive questionnaire (DEX), Cognitive Failure Questionnaire (CFQ),<br /><br>Utrechtse Schaal voor Evaluatie en Revalidatie- Participatie (USER-P),<br /><br>Instrumental activity of daily life scale (IADL), en Short Form Health Survey<br /><br>(SF-36)<br /><br>5) Imaging analyses (resting state fMRI, Diffusion Tensor Imaging, Voxel Based<br /><br>Morphometry)</p><br>