Computer based cognitive flexibility training after stroke
- Conditions
- Stroke patients
- Registration Number
- NL-OMON22908
- Lead Sponsor
- niversity of Amsterdam
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 120
Key inclusion criteria: 1) Suffered from stroke and referred to rehabilitation; 2) Presence of cognitive dysfunction due to stroke; 3) Age between 30 and 80 years; 4) Daily access to computer with internet connection and able to use mouse; 5) lnformed consent for study participation.
Key exclusion criteria: 1) Any disease other than stroke which results in severe cognitive impairments 2) Severe psychological, psychiatric, or somatic comorbidity which could strongly influence the performance on the neuropsychological assessment and training possibilities 3) Mentally (TICS score < 26) and physically (medically unstable) not fit enough to complete training protocol. 4) Aphasia, neglect, paresis or paralysis of the preferred hand, colorblindness, invalidating vision or hearing problems, or severe computer fear.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Executive functioning as measured by neuropsychological tasks (category and letter fluency, Tower of London, D-Kefs TMT number-letter switching, Wechsler Adult Intelligence Scale Letter-Number Sequencing). <br /><br>The groups will be compared immediately before training and immediately after training.<br>
- Secondary Outcome Measures
Name Time Method 1) Cognitive flexibility as measured by switch-cost (reaction times on switch trials compared to reaction times on non–switch trials) on the switch task.<br /><br>2) Cognitive functioning as measured by neuropsychological tasks (Trail Making Test condition B corrected for A, Paced Auditory Serial Addition Task, Digit-Symbol-Coding, Rey’s auditory verbal learning test, Operation span, N-back, Corsi task, Raven Colored Progressive Matrices, Shipley Institute of Living Scale-2, D-Kefs TMT motor speed condition, Mouse skills tasks, and stop-signal task). <br /><br>3) Training improvement<br /><br>4) Subjective cognitive functioning and functioning in daily life as measured by: dysexecutive questionnaire (DEX), Cognitive Failure Questionnaire (CFQ), Utrechtse Schaal voor Evaluatie en Revalidatie- Participatie (USER-P), Instrumental activity of daily life scale (IADL), en Short Form Health Survey (SF-36)<br /><br>5) Imaging analyses (resting state fMRI, Diffusion Tensor Imaging, Voxel Based Morphometry)<br><br>