Computer based training of executive functions in children with an autism spectrum disorder.

Conditions: autism
autism spectrum disorder
10012562

Registration Number: NL-OMON34346

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 102

Inclusion Criteria

1) A diagnosis of an autism spectrum disorder
2) A diagnosis confirming score on the Social Responsiveness Scale and ADI-R.
3) Age between 8-12 years
4) IQ above 80

Exclusion Criteria

1) Epilepsy

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1) Cognitive flexibility: switchcosts (reaction time (RT) on switchtrials<br /><br>compared to non-switchtrials) on the Gender/emotion switch task and Number<br /><br>switch task).<br /><br>2) Working memory: number correct on the Corsi Block Tapping Task and n-back<br /><br>task.<br /><br>3) AD/HD symptoms: score on the Disruptive Behavior Disorder rating scale (DBD).<br /><br>4) Social skills: score on the Children*s Social Behavior Questionnaire (CSBQ).<br /><br>See studyprotocol for further information about these tasks and questionnaires.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1) Inhibition: Stop-reaction time on the Stop task.<br /><br>2) AD/HD symptoms: number correct on the Sustained attention response task (the<br /><br>SART).<br /><br>3) EF (all) (Behavior Rating Inventory of Executive Function questionnaire<br /><br>(BRIEF).<br /><br>4) Quality of Life (Pediatric Quality of Life Inventory, PedsQL).<br /><br><br /><br>ToM (score on the Strange Stories Test), punnishment reward sensitivity (score<br /><br>on the BIS/BAS Questionnaire, RT and number correct on a reward vs. neutral<br /><br>version of the Eriksen flanker paradigm), and motivation (score on the VAS<br /><br>scale) will be included as predictors of improvement as a result of the<br /><br>program.<br /><br><br /><br>See studyprotocol for further information about these tasks and questionnaires.</p><br>