Study of the effect of inspiratory muscle training on endothelial function, autonomic control, exercise capacity of life in patients with pulmonary hypertension.
- Conditions
- I27.0Primary pulmonary hypertension
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- Not specified
Target sample:32 patients. Patients with pulmonary hypertension confirmed by right heart catheterization; the patient must be over 18 years; patients belonging to group I of pulmonary hypertension; patient in functional class II or III of world health organization; patients with specific drug treatment for pulmonary hypertension stable for at least three months; patients willing to complete the training; patients with inspiratory muscle strength less than 70% predicted.
Patients using oxygen; patients with significant musculoskeletal disorders, intermittent pain; cognitive or neurological deterioration; patients with psychiatric-psychological disorders that may interfere in the understanding of the protocol; patients with a history of moderate or severe chronic lung disease; patients with hemodynamic instability; unstable angina or uncontrolled cardiac arrhythmia; patients who were hospitalized in the last three months; patients who participated in supervised exercise programs in the past three months; patients with inspiratory muscle strength more than 70% predicted.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Improvement in exercise endurance capacity.<br>It is assessed by the endurance constant test by cycle ergometer. <br>The result will be above 270 seconds of the baseline time of the exercise tolerance with same load.
- Secondary Outcome Measures
Name Time Method Equilibrium in the sympathetic and parasympathetic modulation balance measured by spectral analysis obtained from the ECG. There are no absolute numbers for such an assessment, but a balance between the sympathetic and parasympathetic modulations (50% each one).;Increase in muscle strength measured by manuvacuometer with result an increase greater than 70% of the value predicted.;Improvement of functional capacity measured by the six-minute walk test, with an increase over 32 meters in the walk distance.;Improvement of physical and mental summarized domains measured by the questionnaire of quality of life SF36 from baseline data with an increase at least 3 points in each domain (physical and mental).;Improvement in endothelial function measured by brachial artery ultrasound with results proving an increase of at least 8% of the vessel elasticity.