Effect of prolonged Theta burst stimulation on pain perception

Recruiting

Registration Number: CTRI/2022/05/042876

Lead Sponsor: All India Institute of Medical Sciences New Delhi

Brief Summary: This study looks into the effect of prolonging the duration of continuous and intermediate theta burst stimulation protocols on corticomotor excitability and pain perception. The limited studies so far have shown inconclusive results for prolonged continuous theta burst stimulation and prolonged intermediate theta burst protocol yet to be explored. This study will help us to conclude whether or not prolonged TBS protocols are as useful as the conventional protocols . It would take 20-30 min to assess baseline CME and QST parameters followed by 1.5 to 5 min of prolonged TBS, then CME at 5 min post stimulation. This will be followed by 45 min rest and again 20-30 min to assess final CME and QST parameters. Null Hypothesis in this study is that the prolonged TBS protocols have no effect on CME and Pain perception with the alternative hypothesis being that either prolonged continuous or prolonged intermediate or both TBS protocols have an effect on either corticomotor excitability or pain perception or both.

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: All

Target Recruitment: 36

Inclusion Criteria

right handed healthy.

Exclusion Criteria

chronic pain disorders pregnant or lactating neuropsychiatric illness on medication for neuropsychiatric illness known case of epilepsy subject with metal implants.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Corticomotor Excitability	Before Stimulation \| 5 mins after stimulation \| 50 min after stimulation

Secondary Outcome Measures

Name	Time	Method
Tactile And Pain threshold and Tolerance for Temperature and Pressure	Before Stimulation

Trial Locations

Locations (1): All India Institute of Medical Sciences New Delhi
🇮🇳
West, DELHI, India
All India Institute of Medical Sciences New Delhi
🇮🇳West, DELHI, India
Dr Renu Bhatia
Principal investigator
8860169671
renuaiims28@gmail.com