The Immediate Effects of Intermittent Theta Burst Stimulation on Intracortical Excitability of the Primary Motor Cortex in Patients With Chronic Stroke: A Concurrent TMS-EEG Sham-controlled Crossover Study
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Stroke
- Sponsor
- The Hong Kong Polytechnic University
- Enrollment
- 21
- Locations
- 1
- Primary Endpoint
- Motor evoked potential (MEP)
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
This study is to investigate the immediate effects of intermittent theta burst stimulation (iTBS) on intracortical excitatory and inhibitory circuits, neural connectivity, and network properties in patients with chronic stroke, using transcranial magnetic stimulation and electroencephalogram (TMS-EEG) and TMS-electromyography (EMG) and approaches.
Detailed Description
The neurophysiological effect of intermittent theta burst stimulation (iTBS) has been examined with TMS-electromyography (EMG)-based outcomes in healthy people; however, its effects in intracortical excitability and inhibition are largely unknown in patients with stroke. Concurrent transcranial magnetic stimulation and electroencephalogram (TMS-EEG) recording can be used to investigate both intracortical excitatory and inhibitory circuits of the primary motor cortex (M1) and the property of brain networks. This study is to investigate the immediate effects of iTBS on intracortical excitatory and inhibitory circuits, neural connectivity, and network properties in patients with chronic stroke, using TMS-EEG and TMS-EMG approaches. In this randomized, sham-controlled, crossover study, 21 patients with chronic stroke receive two separate stimulation conditions: a single-session iTBS or sham stimulation applied to the ipsilesional M1, in two separate visits, with a washout period of five to seven days between the two visits after crossover. A battery of TMS-EMG and TMS-EEG measurements are taken before and immediately after stimulation during the visit.
Investigators
Kenneth N. K. Fong
Professor in Rehabilitation Sciences
The Hong Kong Polytechnic University
Eligibility Criteria
Inclusion Criteria
- •suffered from first-ever, ischemic or hemorrhagic, unilateral stroke, verified by neuroimaging examinations such as CT or MRI.
- •detectable motor evoked potentials from the affected first dorsal interosseous muscle;
- •provided written informed consent.
Exclusion Criteria
- •had any contraindication to transcranial magnetic stimulation;
- •had a known neurological disease excluding stroke, or psychiatric disease;
- •were using a psychostimulant, sedative, antidepressant, or antiepileptic medication.
Outcomes
Primary Outcomes
Motor evoked potential (MEP)
Time Frame: 10 minutes after a single-session iTBS stimulation
Single TMS pulses with suprathreshold intensity (120% of resting motor threshold of the stimulated cortex) applied to the primary motor cortex (M1) can produce recordable MEPs in contralateral muscles; additionally, the peak-to-peak amplitude of MEPs can be used to represent the corticospinal excitability
Transcranial magnetic stimulation-evoked potential
Time Frame: 10 minutes after a single-session iTBS stimulation
Single pulses evoked an initial response in electroencephalogram, followed by a series of time- and phase-locked positive and negative deflections which could spread to the connected brain areas. The evoked potential is called transcranial magnetic stimulation-evoked potential.
Secondary Outcomes
- Cortical silent period(10 minutes after a single-session iTBS stimulation)
- Short-interval intracortical inhibition(10 minutes after a single-session iTBS stimulation)
- Intracortical facilitation(10 minutes after a single-session iTBS stimulation)