Improvement of endogenous regeneration in female healthy volunteers through physical exercise REBIRTH aktiv women”
Not Applicable
- Conditions
- Healthy female volunteers
- Registration Number
- DRKS00005159
- Lead Sponsor
- MHH - HTTG Chirurgie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 296
Inclusion Criteria
Females (45 - 65 years old) with a mainly sedentary way of work and no physical activity during leisure time.
Exclusion Criteria
- smoker -diabetes mellitus - operations during the last 8 weeks - artificial joint replacement less then 6 months before the start of the study - coronary/arterial disease - not medicamentous adequately treated hypertension - cancer - other diseases that interfere with physical activity.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Differences in telomere length in mononuclear cells (cells will be drwan from venous blood) between baseline and after 6 months intervention. Peak oxygen consumption (VO2peak) at baseline and after 6 months.
- Secondary Outcome Measures
Name Time Method Measurements from venous blood:<br>Oxidative stress (malondialdehyd, nitrate, nirtite), OxLDL, sodium, potassium, calcium, magnesium, phosphate, glucose, bilirubin, creatinine (eGFR), urea, urea acid, cholesterol, LDL cholesterol, HDL cholesterol, triglyceride, creatinkinase, Gamma-GT, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, ferritin, hs CRP, cystatine C, transferrinrezeptor, TSH, NTproBNP, LH, FSH, estradiol, progesterone, ex vivo stimulationtest TFNalpha. <br>Additionally, for later analyses of new or newly relevant parameters/biomarkers aliquots will be stored in the unified biobank hannover.<br>Measurements from arterialized capillary blood: lactate, glucose.<br>Measurement from Saliva: ROS.<br>Questionnaires:<br>WorkAbilityIndex, SF36, nutrition analyses<br>Other Measurements: systolic and diastolic blood pressure<br>Each measurement will be done at baseline and after 6 months.