Investigation on exhaled nitrogen chemicals in patients undergoing abdominal surgery

Not Applicable

• Conditions: abdominal surgery

• Registration Number: JPRN-UMIN000037442
• Lead Sponsor: Division of Anesthesiology and Critical Care Medicin, Tottori University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-07-22
• Study Completion: 2023-03-31
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Not provided

Exclusion Criteria

1) patients undergoing surgery requiring general anesthesia within 3 months prior to obtaining informed consent 2) patients with acute respiratory failure (pneumonia, acute respiratory distress syndrome etc.) 3) patients who undergo emergency surgery 4) patients with sepsis or septic shock 5) Patients with progressive neuromuscular disease 6) Patients undergoing thoracic surgery 7) highly obese patients (BMI 35 kg / m2 or more) 8) women who are pregnant or have pregnancy possibility 9) patients who received study drugs or investigational drugs within 3 months prior to obtaining informed consent 10) patinets whom research investigator has determined to be inappropriate

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
change in exhaled NO, NO2, HONO concentration during perioperative period

Secondary Outcome Measures

Name	Time	Method
1) relevance of exhaled NO, NO2, HONO and blood ROS during perioperative period 2) relevance of exhaled NO, NO2, HONO and blood cytokines during perioperative period 3) relevance of exhaled NO, NO2, HONO and blood biomarkers during perioperative period 4) relevance of exhaled NO, NO2, HONO and hematological examination, blood biochemical examination, arterial blood gas analysis examination during perioperative period 5) relevance of exhaled NO, NO2, HONO and pulmonary function during perioperative period 6) Whether the exhaled NO, NO2 and HONO concentrations are related to the anesthesia method during perioperative period 7) Whether the exhaled NO, NO 2 and HONO concentrations in the perioperative period are related to the operation conten