EVALUATION OF THE EFFECT OF ADDING GNRH AGONIST TO THE DUAL PROGESTERONE (INTRAMUSCULAR AND VAGINAL) AS LUTEAL PHASE SUPPORT IN FROZEN-THAWED EMBRYO TRANSFERS DURING ARTIFICIAL CYCLES: A RANDOMIZED CONTROLLED TRIAL.
Not Applicable
Completed
- Conditions
- Health Condition 1: N979- Female infertility, unspecified
- Registration Number
- CTRI/2021/09/036421
- Lead Sponsor
- Angels Fertility Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
a.Patients undergoing IVF/ICSI cycles using FET.
b. Age between 20 to 40 years.
c. Antagonist cycles
d. Given P4 and E2 or P4, E2 plus GnRH agonist as LPS.
e. Written informed consent.
Exclusion Criteria
a. Uterine fibroid if encroaching uterine cavity.
b. Mullerian anomalies.
c. Ovarian endometrioma.
d. Polycystic ovarian syndrome (PCOS).
e. Use of donor sperms or oocytes.
f. Adnexal hydrosalpinx except after disconnection.
g. Allergy to triptorelin.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. To determine Biochemical Pregnancy (Positive urine test or serum �²-HCG50m IU/ml after 14 days of embryo transfer). <br/ ><br>2. To determine Clinical Pregnancy Rate (Presence of gestational sac or fetus heartbeat at 4-weeks after embryo transfer or 6-7 weeks or pregnancy). <br/ ><br>3. To determine implantation rate (Number of gestational sacs divided by the number of embryos transferred). <br/ ><br>4. To determine Ongoing Pregnancy Rate (Pregnancy contouring beyond 12 weeks of pregnancy).Timepoint: 1. To determine Biochemical Pregnancy (Positive urine test or serum �²-HCG50m IU/ml after 14 days of embryo transfer). <br/ ><br>2. To determine Clinical Pregnancy Rate (Presence of gestational sac or fetus heartbeat at 4-weeks after embryo transfer or 6-7 weeks or pregnancy). <br/ ><br>3. To determine implantation rate (Number of gestational sacs divided by the number of embryos transferred). <br/ ><br>4. To determine Ongoing Pregnancy Rate (Pregnancy contouring beyond 12 weeks of pregnancy).
- Secondary Outcome Measures
Name Time Method To determine the incidence of OHSSTimepoint: Continious monitoring during the study.;To determine the Miscarriage Rate.Timepoint: Upto 10 weeks of gestation;To determine the Multiple Pregnancy RateTimepoint: Pregnancy with 2/more fetuses;To determine the role of GnRH agonist as LPS agent in FET antagonist IVF/ICSI cycles based on womens age and duration of infertility.Timepoint: At the end of the study.