Functional Renal Hemodynamics in Patients with Renal Artery Stenosis 3

Recruiting

• Conditions: narrowing of the renal artery; Renovascular disease; 10038430; 10057166

• Registration Number: NL-OMON48149
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

Age > 18
Written informed consent
Clinical indication for percutaneous transluminal renal angioplasty
Clinically and hemodynamically stable
CT-angiogram or MR-angiogram of the renal arteries
Renography

Exclusion Criteria

Known atrial fibrillation with irregular ventricular response rate
Increased risk for contrast nephropathy defined as presence of renal impairment
(eGFR <30ml/min) according to the Guideline Safe Use of Contrast Media of the
Radiology Society of the Netherlands (November 2017)
Women of child bearing age not on active birth control
Inability to sign an informed consent, due to any mental condition that renders
the
subject unable to understand the nature, scope, and possible consequences of
the trial or due to mental retardation or language barrier

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Receiver operating characteristics for predicting ambulatory blood pressure<br /><br>response after renal angioplasty by (1) the hyperemic pressure gradient, (2)<br /><br>the hyperemic pressure gradient and the renal flow reserve. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The level of agreement between the CFD-predicted hyperemic pressure drop and<br /><br>the invasively measured pressure drop.</p><br>