Functional Renal Hemodynamics in Patients with and without Renal Artery Stenosis 2
- Conditions
- Renal artery stenosis, renovascular disease, hypertension, chronic kidney disease
- Registration Number
- NL-OMON24285
- Lead Sponsor
- Academic Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 16
Age > 18
Written informed consent
Clinically and hemodynamically stable
Clinical indication for a coronary, renal, or peripheral vascular angiography with or without percutaneous intervention.
Recent ST-segment elevation myocardial infarction (<6 weeks prior to enrolment)
Known cardiac arrhythmias Known heart failure (NYHA class > II)
Increased risk for contrast nephropathy defined as presence of renal impairment (eGFR <30ml/min) according to the Guideline Safe Use of Contrast Media of the Radiology Society of the Netherlands (November 2017) Women of child bearing age not on active birth control
Inability to sign an informed consent, due to any mental condition that renders the subject unable to understand the nature, scope, and possible consequences of the trial or due to mental retardation or language barrier
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Dynamic range of renal blood flow, represented by the relative baseline flow (RBF), the ratio between the difference of baseline and minimal flow velocity and baseline flow velocity.
- Secondary Outcome Measures
Name Time Method Renal flow reserve, relative minimal flow, renal fractional flow reserve, baseline and hyperemic renal stenosis resistance, baseline and hyperemic microvascular resistance, phase difference in sympathetic band for autoregulation. In patients where offline renal perfusion analysis is possible: renal perfusion as area under the curve of contrast density over time and the renal flow reserve computed by perfusion angiography.<br>Correlation of main study parameters with relevant clinical, biochemical and imaging parameters.