Functional renal hemodynamics in patients with and without renal artery stenosis

Completed

• Conditions: atherosclerotic renal artery stenosis; renal artery calcification; 10038430; 10057166

• Registration Number: NL-OMON47085
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Subjects who have provided written informed consent
Subjects who are >=18 yrs and <=75 years of age
Subjects who are clinically stable
Subjects with an indication for coronary angiography, renal angiography or percutaneous transluminal renal angioplasty (PTRA)
Subjects who are willing and able to comply with all study procedures

Exclusion Criteria

Acute coronary syndrome
Cardiac arrhythmias
Heart failure (NYHA class > II)
Severe valvular heart disease
Severe renal artery stenosis (>90 % diameter stenosis)
Severe renal impairment (eGFR <30ml/min) or clinical indication for prehydration
according to the 2007 CBO Contrast induced nephropathy guidelines

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To assess the feasibility and reproducibility of intravascular measurements of<br /><br>pressure and flow velocity in renal arteries and derived diagnostic parameters<br /><br>(hyperemic stenosis resistance, baseline and hyperemic microvascular<br /><br>resistance, renal flow reserve) in patients with a history of hypertension<br /><br>undergoing elective cardiac catheterization with pressure and flow<br /><br>measurements. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>N/A</p><br>