Comparison of 3-weekly administration of continuous dose cisplatin with divided dose in head and neck carcinoma

Phase 2

• Conditions: Condition 1: Malignant neoplasm of base of tongue. Condition 2: Malignant neoplasm of other and unspecified parts of tongue. Condition 3: Malignant neoplasm of oropharynx. Condition 4: Malignant neoplasm of nasopharynx. Condition 5: Malignant neoplasm of hypopharynx. Condition 6: Malignant neoplasm of pyriform sinus. Condition 7: Malignant neoplasm of larynx.; Malignant neoplasm of base of tongue; Malignant neoplasm of other and unspecified parts of tongue; Malignant neoplasm of oropharynx; Malignant neoplasm of nasopharynx; Malignant neoplasm of hypopharynx; Malignant neoplasm of pyriform sinus; Malignant neoplasm of larynx

• Registration Number: IRCT20201220049776N1
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Men and women under 70 years of age, known case of head and neck SCC with karnofsky performance status >= 70%
Definitive chemoradiation or adjuvant chemoradiation in patients with extranodal extension or positive margin
Radiation dose 66-70 Gy

Exclusion Criteria

History of chemotherapy
Kidney disease and Diabetes

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mucositis. Timepoint: Weekly during radiation for 7 weeks. Method of measurement: Examination.;Disphasia. Timepoint: Weekly during radiation for 7 weeks. Method of measurement: Examination.;Cytopenia. Timepoint: Weekly during radiation for 7 weeks. Method of measurement: Laboratory data.

Secondary Outcome Measures

Name	Time	Method
Disease free survival. Timepoint: 18 months. Method of measurement: Phone calls. Visit at the Office.;Overall survival. Timepoint: 18 months. Method of measurement: Phone calls. Visit at the Office.