A randomised trial of blood pressure maintenance using angiotensin II versus noradrenaline in cardiac surgery patients to determine effect on length of hospital stay

Phase 3

Recruiting

• Conditions: Cardiac surgery; Hypotension; Anaesthesiology - Other anaesthesiology; Cardiovascular - Diseases of the vasculature and circulation including the lymphatic system

• Registration Number: ACTRN12623000848606
• Lead Sponsor: Alfred Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-08-08
• Last Update Posted: 22 January 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

1. Coronary artery bypass grafting (CABG) surgery, valve repair or replacement (VR) surgery or a combination of CABG and VR surgery
2. Elevated risk of acute kidney injury as predicted by any of the following:
a) Haemoglobin <130g/l
b) Creatinine > 100mmol/l
c) Age > 70 years
d) New York Heart Association classification 4
e) Body Mass Index > 30 kg/m2

Exclusion Criteria

1. Major aortic surgery, transplant surgery, pulmonary thrombendarterectomy or ventricular assist device surgery
2. Already receiving inotropic or vasopressor support
3. Dialysis dependent, prior renal transplant
4. Pre-existing significant hypertension (systolic blood pressure > 180mm Hg)
5. Significant pulmonary hypertension (estimated systolic pulmonary artery pressure (PAP) > 70mmHg, mean PAP > 40mmHg) AND right ventricular systolic dysfunction (graded more severe than mild)
6. Pregnant or breastfeeding women

Study & Design

• Study Type: Interventional
• Study Design: Not specified