The Pathogenesis of Large Intestine Damp-heat Syndrome in Ulcerative Colitis Based on Pathways Related with Microbiome-Gut-Brain Axis

Phase 1

• Conditions: lcerative Colitis

• Registration Number: ITMCTR1900002265
• Lead Sponsor: Beijing University of Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Those who meet the diagnostic criteria of Western medicine and TCM syndromes for mild or moderate UC in active stage, or those who routinely screen for physical examination;
2. The lesion does not exceed sigmoid colon;
3. Aged 18 to 65 years;
4. agree to participate in this study and sign the informed consent.

Exclusion Criteria

1. Complicated with severe complications or history of abdominal surgery, such as toxic megacolon, intestinal obstruction, stricture, perforation and canceration;
2. Complicated with serious diseases such as hematopoietic system, liver, kidney and endocrine system (diabetes, metabolic syndrome, cancer, etc.) or psychiatric diseases;
3. alcoholism or drug addiction;
4. Pregnancy or lactation;
5. Participate in other clinical research
6. used antibiotics within past 3 months; used gastrointestinal motility drugs, acid inhibitors, microecological agents or immunosuppressants in past 3 weeks.

Study & Design

• Study Type: Basic Science
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Metabonomics;cytokine;intestinal microbiome;