Study on biological basis of damp heat syndrome of glycolipid metabolic diseases

Phase 4

• Conditions: Diabetes

• Registration Number: ITMCTR2200005531
• Lead Sponsor: Dongzhimen Hospital, Beijing University of Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

?there were 20 patients who met the diagnostic criteria of type 2 diabetes and TCM criteria for non dampness heat syndrome.? Conforms to the diagnostic criteria of damp heat syndrome of Chinese medicine and one of the diagnostic criteria for obesity or hyperlipidemia, and the subjects have no risk factors for type 2 diabetes, namely, fasting plasma glucose level < 100 mg/dL, glycosylated hemoglobin (HbA1c) < 5.7% (normal glucose metabolism), 20 cases. ? There were 20 healthy people. 40 = age = 75, regardless of gender, sign informed consent.

Exclusion Criteria

Patients with primary diseases of heart, liver, kidney, endocrine system or acute and chronic gastrointestinal diseases; Patients with mental illness; Pregnant or lactating patients; Taking drugs that may affect intestinal flora in recent 2 months, such as antibiotics, berberine, defecation drugs, bifidobacteria, etc; Those who had received external enema therapy within 1 month were sampled.

Study & Design

• Study Type: Observational study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Blood sample proteomics;glycosylated hemoglobin;Urinary creatinine;Detection of water molecules in blood samples;urinalysis;routine blood test;Urine sample proteomics;electrocardiogram;Detection of inflammatory factors and cytokines in blood samples;Western blot verification of blood samples;Blood biochemistry;Stool routine;Detection of water molecules in urine samples;Fundus color photograph examination;Fasting and postprandial blood glucose;Metabolomics of urine samples;Tongue color photo examination;Metabolomics of blood samples;Urinary microalbumin;Single cell sequencing of blood samples;Stool sample flora detection;