Long-term Brain Health of Retired Professional Rugby Players, With a History of Concussion/Head Impact Exposure

• Conditions: Brain Health Retired Elite Athletes
• Interventions: Other: Exploratory brain and general health assessment

• Registration Number: NCT03544346
• Lead Sponsor: University of Dublin, Trinity College

Brief Summary

There has been significant recent interest on the issue of brain health in athletes. Participation in sports is generally viewed as extremely positive. Consistent evidence supports associations among exercise, cognitive vitality, neural functioning and decreased risk of cognitive decline. However, In the last decade, a dramatic shift in both public and scientific perception around the long-term consequences of concussion is evident. Rugby is a popular full-contact sport played throughout the world at varying levels of competition, including professional level. The game exposes players to inherent risk of injury including repetitive head impacts, due to the high number of collisions and tackles involved. Perhaps not surprisingly, given the physical nature of the sport, rugby has one of the highest rates of concussion of all full-contact sports. Evidence from a recent meta-anaysis found the incidence of concussion to be 4.73 per 1000 player match hours. Given the high incidence of concussion that has been reported in the literature to date, the issue of concussion and repeated head impact exposure is of particular concern in rugby.

Comprehensive investigation of cognition in living retired sports persons with previous exposure to repetitive head impact is noticeably lacking in the literature to date. Findings are inconsistent and investigations are shrouded by consistent methodological biases and flaws, reducing the overall quality of the studies. Relatively little research has been conducted on the long-term effects of repetitive mild TBI or sports concussion on the retired athlete's brain health with ageing. The potential long-term consequences are poorly understood and warrant more research. This study aims to investigate the brain health of retired rugby players in comparison to retired rowers who have achieved the same levels of exercise, without exposure to SRCs

Detailed Description

The primary aim of this study is to investigate brain health and wellness of retired professional Irish rugby players in comparison to retired professional Irish rowers.

Objectives:

The objectives will be to:

Obtain detailed demographic and overall health information from the retired rugby players and retired rowers.

Use a battery of cognitive function tests to assess the cognitive health of the retired rugby players and retired rowers.

Obtain blood samples from the retired rugby players and retired rowers in order to test for biomarkers indicative of neurodegenerative disease.

Investigate rugby player's self-report history of sports-related concussion (number and nature of concussions) during their career. Player's self-report will be correlated where possible with established individual player medical data.

Study Timeline

• Status Verified: 2018-05
• Study First Submitted: 2018-05-21
• Study First Submitted QC: 2018-05-21
• Last Update Submitted: 2018-05-21
• Study First Posted: 2018-06-01
• Last Update Posted: 2018-06-01
• Study Start: 2018-06-18
• Primary Completion: 2018-12-15
• Study Completion: 2018-12-15

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 200

Inclusion Criteria

• Male A retired professional rugby player (no age limit), who has played at least one season of professional rugby. A retired international rower (no age limit), who completed and trained full time for at least one season.

Athletes who have given informed consent and are willing to participate in the study.

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Exclusion Criteria

• You have a history of a non-sports related moderate to severe concussion or brain injury (eg a motor vehicle accident) You have had a concussion in the last year. You have had treatment of chemotherapy or radiotherapy in last 12 months. You have a bleeding disorder (will exclude you from blood sampling only).

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Retired professional rowers	Exploratory brain and general health assessment	Rowers will Provide detailed demographic information Provide detailed overall health information Questionnaires Provide information on athlete's playing career; age of debut, career duration, number of seasons participated in. Provide information on concussion history. Be given a general health screen including- heart rate, blood pressure, body composition and height weight ratio. Perform a battery of neuropsychological tests (Sound-induced flash illusion and CANTAB, NART) Provide a sample of blood.
Retired professional rugby players	Exploratory brain and general health assessment	Rugby Players will Provide detailed demographic information Provide detailed overall health information Questionnaires Provide information on athlete's playing career; age of debut, career duration, number of seasons participated in. Provide information on concussion history. Be given a general health screen including- heart rate, blood pressure, body composition and height weight ratio. Perform a battery of neuropsychological tests (Sound-induced flash illusion and CANTAB, NART) Provide a sample of blood.

Primary Outcome Measures

Name	Time	Method
Brain Health Assessment	1 hour	Investigating cognitive functioning

Secondary Outcome Measures

Name	Time	Method
Concussion History Assessment	20 minutes	History of concussion/head impact exposure