Comparison of oral and intravenous paracetamol plasma levels when given as premedication for perioperative analgesia - Paracetamol Study

orth Bristol NHS Trust0 sites104 target enrollmentStarted: July 23, 2006Last updated: June 30, 2019

Conditions

Drugs

Trial Snapshot

No summary available.

•1) ASA I and II (Patients who are fit medically or only have mild systemic disease, for example treated high bloodpressure -
•disease that does not limit daily activities)
•2) Age group 16 – 75 years (to exclude children who can not give consent)
•3) Specific operative list: Mr. P Robinson Ear, Nose & Throat surgery
•This patient group will benefit from the type of pain relief effect that paracetamol has.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

•1) Patients refusing to participate in study.
•2) Patient unable to take an oral preparation.
•3) Cases shorter than one hour.(Less than that to short to complete bloodtest and all paperwork for anaesthetic)
•4) Patients already taking a paracetamol containing drug combination, or have taken in the last 12 hrs.(Bloodlevels will be
•5) Patients with a history of paracetamol allergy, hypersensitivity or previous reaction / serious adverse reaction.
•6) Children under the age of 16 (Can not give consent)
•7) Patients unable to understand or give consent to participation in the study; incapable adults, psychiatric / medical disorder
•able to modify patient compliance.
•8) Pregnant or breastfeeding
•9) History of complete non-responsiveness to acetaminophen (Paracetamol)
•10) Pancreatic disease in the previous 12 months (Influences the metabolism of paracetamol)
•11) Impaired liver/ kidney function
•12) (Patients that might pose an infection risk to staff – blood products)
•A24. Will the participants be from any of the following groups?(Tick as appropriate)

Sponsor

orth Bristol NHS Trust